Infection and infective endocarditis according to type of diabetes mellitus after cardiac implantable electronic device implantation: a contemporary nationwide cohort study

Abstract Background Patients with diabetes mellitus (DM) are at increased risk of infection. However, there controversial reports about type 1 or 2 DM and their associations infection infective endocarditis (IE) following implantation cardiac implantable electronic device (CIED). We evaluated the contemporary incidence infections a first-time, permanent CIED in patients compared to controls. Methods This French longitudinal cohort study was based on national hospitalization database covering hospital care from for entire population. All adults hospitalized hospitals 2010 2019, who underwent de novo pacemaker (PM) cardioverter defibrillator (ICD) were identified together occurrence post-implantation IE-events during follow-up. Results In total 688,007 (pacemakers 87.3%, ICDs 12.7%). History present 162,490 patients: 8,041 (1.2%) 154,449 (22.5%) DM. no slightly older had less prevalent associated comorbidities than those Follow-up 2.6±2.6 years (median 1.9, IQR 0.2–4.3 years). There 9,804 CIED-related follow-up (incidence rate 5.48 per 1000 patient.year) among whom 2,658 IE 1.49 patient year). The (per PYs) different subgroups DM, Table 1. Incidence rates higher numerically multivariable analysis (adjustment baseline characteristics including age, cardiovascular non-cardiovascular CIED), independent factors vs Type not statistically When analysing FU, an whilst non-statistical trend however similar when one considered separately periods 2010–2014 2015–2019 Conclusion significantly Although differences profile clinical history statistical difference this nationwide level. Funding Acknowledgement funding sources: None.